• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Metabolic syndrome and morpho-functional characteristics of the left ventricle in clinically hypertensive nondiabetic subjects.
【2h】

Metabolic syndrome and morpho-functional characteristics of the left ventricle in clinically hypertensive nondiabetic subjects.

机译：临床高血压非糖尿病受试者的左心室代谢综合征和形态功能特征。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND:\udThe study was aimed to evaluate the impact of the metabolic syndrome on left ventricular (LV) structure and function in nondiabetic patients, never treated with antihypertensive or lipid-lowering drugs.\udMETHODS:\udEighty-eight patients, with recent finding of clinic BP >140 or 90 mm Hg, underwent 24-h blood pressure (BP) monitoring, echocardiogram, evaluation for metabolic syndrome (Adult Treatment Panel III criteria).\udRESULTS:\udMetabolic syndrome was diagnosed in 38 subjects (43.2%) (metabolic syndrome+). Age, gender, 24-h systolic and diastolic BP were similar between metabolic syndrome+ and metabolic syndrome- groups, whereas body mass index, clinic and 24-h heart rate, fasting glycemia, and triglycerides were significantly higher and HDL-cholesterol lower in metabolic syndrome + subjects. The prevalence of sustained hypertension (24-h BP >125 or 80 mm Hg) was similar between the two groups. Relative wall thickness and LV mass were significantly greater in the metabolic syndrome+ group, also after correction for body mass index. The LV systolic function was similar between the two groups, whereas all the parameters of diastolic function, but the mitral E/A ratio, were significantly lower in the metabolic syndrome+ group. From multiple regression analysis the main independent determinant of LV mass index was the presence of metabolic syndrome, followed by the 24-h systolic BP.\udCONCLUSIONS:\udNondiabetic patients with metabolic syndrome showed more pronounced alterations of LV geometry and function compared with subjects without metabolic syndrome. These greater preclinical myocardial abnormalities were not accounted for by difference in age, gender, or 24-h BP and can be reasonably ascribed to the interplay of the metabolic syndrome components, making the metabolic syndrome in itself a relevant clinical problem, possibly a cardiovascular disease equivalent, that deserves aggressive treatment.
机译：背景：\ ud这项研究旨在评估未使用降压药或降脂药治疗的非糖尿病患者代谢综合征对左心室（LV）结构和功能的影响。\ udMETHODS：\ ud88例患者，最新发现临床血压> 140或90 mm Hg，进行24小时血压（BP）监测，超声心动图，代谢综合征评估（成人治疗小组III标准）。\ ud结果：\ ud代谢综合征被诊断为38位受试者（43.2％） （代谢综合征+）。代谢综合征+组和代谢综合征组之间的年龄，性别，24小时收缩压和舒张压相似，而代谢中的体重指数，临床和24小时心率，空腹血糖和甘油三酸酯显着升高，而HDL-胆固醇降低综合症+受试者。两组之间持续高血压的患病率（24-h BP> 125或80 mm Hg）相似。在校正了体重指数之后，新陈代谢综合症+组的相对壁厚和左室重量明显更大。两组的LV收缩功能相似，而代谢综合征+组的所有舒张功能参数，但二尖瓣E / A比均显着降低。通过多元回归分析，左室重量指数的主要独立决定因素是是否存在代谢综合征，其次是24小时收缩压。\ ud结论：\ ud与非糖尿病患者相比，非代谢综合征的非糖尿病患者表现出更明显的LV几何和功能改变代谢综合征。这些较大的临床前心肌异常不是由年龄，性别或24小时血压差异引起的，并且可以合理地归因于代谢综合征成分的相互作用，从而使代谢综合征本身成为相关的临床问题，可能是心血管疾病等效，值得积极对待。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号